PK Biosciences provides fast turnaround for in vivo drug-discovery toxicity studies

In Vivo Toxicity Testing

Determining the liabilities and potential for gross toxicity of NCEs (new chemical entities) and NBEs (new biological  entities) early in the preclinical process can save large amounts of time and money on GLP toxicology studies.  We can tailor a comprehensive testing program to fit each client's needs. Protocols are designed according to NIH guidelines and are conducted in full compliance with Good Laboratory Practice (GLP) regulations. We apply the most sophisticated battery of tests available for the toxicity studies.

PKBio offers customized preclinical discovery-phase rodent toxicity studies in both single escalating and multiple dosing regiments with rapid turnaround.

• Animal behavior
• Food consumption and body weight monitoring
• LD-50
• Maximum tolerated dose (MTD)
• Acute Toxicity
• Subchronic Toxicity
• Chronic Toxicity
• Single dose range-finding and acute toxicity studies
• Repeated Dose
• Sensitization
• Irritation

All standard routes of administration are offered. Our strength is accommodating specialized client needs for treatment regimens.

• Subcutaneous
• Intraperitoneal
• Intravenous
• Intramuscular
• Topical
• Oral
• Controlled release pumps

PKBio study  services offered extend beyond the in-life phase of preclinical testing. The following ancillary, yet integral, services are offered:

• Clinical Pathology
• Gross Pathology
• Histopathology
• Parasitology
• Microbiology
• Toxicokinetics
• Data Analysis
• Report Writing